AUTHOR=Garg Anjali , Kumari Bandana , Kumar Ravindra , Kumar Manish 

TITLE=miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.02053

DOI=10.3389/fmicb.2017.02053

ISSN=1664-302X

ABSTRACT=<p>Autoimmune diseases emerge due to several reasons, of which molecular mimicry i.e., similarity between the host's and pathogen's interacting peptides is an important reason. In the present study we have reported a database of only experimentally verified peptide sequences, which exhibit molecular mimicry. The database is named as <bold>miPepBase (Mi</bold>micry <bold>Pep</bold>tide Data<bold>base</bold>) and contains comprehensive information about mimicry proteins and peptides of both host (and model organism) and pathogen. It also provides information about physicochemical properties of protein and mimicry peptides, which might be helpful in predicting the nature of protein and optimization of protein expression. The <bold>miPepBase</bold> can be searched using a keyword or, by autoimmune disease(s) or by a combination of host and pathogen taxonomic group or their name. To facilitate the search of proteins and/or epitope in miPepBase, which is similar to the user's interest, BLAST search tool is also incorporated. <bold>miPepBase</bold> is an open access database and available at <ext-link ext-link-type="uri" xlink:href="http://proteininformatics.org/mkumar/mipepbase" xmlns:xlink="http://www.w3.org/1999/xlink">http://proteininformatics.org/mkumar/mipepbase</ext-link>.</p>