AUTHOR=Simon Diana , Hernandez Felix , Avila Jesus 

TITLE=The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology

JOURNAL=Frontiers in Neurology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2013.00074

DOI=10.3389/fneur.2013.00074

ISSN=1664-2295

ABSTRACT=<p>Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease (AD). Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the interaction of extracellular tau with M1/M3 muscarinic receptors present in the cholinergic neurons. This interaction between tau and muscarinic receptors may be a way, although not the only one, to explain the spreading of tau pathology occurring in AD.</p>