AUTHOR=Zhao Juanjuan , Yue Dongxu , Zhou Ya , Jia Li , Wang Hairong , Guo Mengmeng , Xu Hualin , Chen Chao , Zhang Jidong , Xu Lin 

TITLE=The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

JOURNAL=Frontiers in Neurology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00342

DOI=10.3389/fneur.2017.00342

ISSN=1664-2295

ABSTRACT=<p>Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system. Recent evidence showed that microRNAs (miRNAs) played important roles in the pathological progression of AD. In this article, we reviewed the promising role of miRNAs in both Aβ deposition and Tau phosphorylation, two key pathological characters in the pathological progression of AD, which might be helpful for the understanding of pathogenesis and the development of new strategies of clinical diagnosis and treatment of AD.</p>