AUTHOR=Nguyen Nam P., Shen Wei , Kratz Sarah , Vock Jacqueline , Vos Paul , Vinh-Hung Vincent , Altdorfer Gabor , Ewell Lars , Jang Siyoung , Karlsson ULF L., Godinez Juan , Mills Melissa , Sroka Thomas , Dutta Suresh , Chi Alexander 

TITLE=Feasibility of Tomotherapy-based image-guided radiotherapy for small cell lung cancer

JOURNAL=Frontiers in Oncology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00289

DOI=10.3389/fonc.2013.00289

ISSN=2234-943X

ABSTRACT=<p><bold>Background</bold>: To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT).</p><p><bold>Materials and Methods</bold>: A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who underwent chemoradiation delivered with helical tomotherapy (HT) has been conducted.</p><p><bold>Results</bold>: Acute grade 3–4 hematologic and esophagitis toxicities developed in two and three patients respectively. One patient developed a pulmonary embolism during radiotherapy. Seven patients had weight loss ranging from 0 to 30 pounds (median: 4 pounds). Three patients had treatment breaks ranging from 2 to 12 days. At a median follow-up of 11 months (range: 2–24 months), no patients developed any radiation related toxicities such as grade 3–4 pneumonitis or other long-term complications. The median survival was estimated to be 15 months. There were two local recurrences, three mediastinal recurrences, and six distant metastases.</p><p><bold>Conclusion</bold>: Grade 3–4 toxicities remained significant during chemoradiation when radiation was delivered with tomotherapy-based IGRT. However, the absence of grade 3–4 pneumonitis is promising and the use of HT needs to be investigated in future prospective studies.</p>