AUTHOR=Hettmer Simone , Bronson Roderick T. , Wagers Amy J. 

TITLE=Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions

JOURNAL=Frontiers in Oncology

VOLUME=5

YEAR=2015

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00050

DOI=10.3389/fonc.2015.00050

ISSN=2234-943X

ABSTRACT=<p>Rhabdomyosarcomas (RMS) are heterogeneous cancers with myogenic differentiation features. The cytogenetic and mutational aberrations in RMS are diverse. This study examined differences in the malignant behavior of two genetically distinct and disease-relevant mouse myogenic tumor models. <italic>Kras; p1619<sup>null</sup></italic> myogenic tumors, initiated by expression of oncogenic <italic>Kras</italic> in <italic>p16p19<sup>null</sup></italic> mouse satellite cells, were metastatic to the lungs of the majority of tumor-bearing animals and repopulated tumors in seven of nine secondary recipients. In contrast, <italic>SmoM2</italic> tumors, initiated by ubiquitous expression of a mutant Smoothened allele, did not metastasize and repopulated tumors in 2 of 18 recipients only. In summary, genetically distinct myogenic tumors in mice exhibit marked differences in malignant behavior.</p>