AUTHOR=Madamba Stephen M. , Damri Kevin N. , Dejean Laurent M. , Peixoto Pablo M. 

TITLE=Mitochondrial Ion Channels in Cancer Transformation

JOURNAL=Frontiers in Oncology

VOLUME=5

YEAR=2015

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00120

DOI=10.3389/fonc.2015.00120

ISSN=2234-943X

ABSTRACT=<p>Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.</p>