AUTHOR=Bourne Roger M. , Bailey Colleen , Johnston Edward William , Pye Hayley , Heavey Susan , Whitaker Hayley , Siow Bernard , Freeman Alex , Shaw Greg L. , Sridhar Ashwin , Mertzanidou Thomy , Hawkes David J. , Alexander Daniel C. , Punwani Shonit , Panagiotaki Eleftheria 

TITLE=Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate

JOURNAL=Frontiers in Oncology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2017.00047

DOI=10.3389/fonc.2017.00047

ISSN=2234-943X

ABSTRACT=<p>This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned <italic>in vivo</italic> and <italic>ex vivo</italic> imaging, <italic>in situ</italic> tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution <italic>ex vivo</italic> imaging aids in registration of <italic>in vivo</italic> MRI and histopathology data.</p>