AUTHOR=Fiz Ivana , Mazzola Francesco , Fiz Francesco , Marchi Filippo , Filauro Marta , Paderno Alberto , Parrinello Giampiero , Piazza Cesare , Peretti Giorgio 

TITLE=Impact of Close and Positive Margins in Transoral Laser Microsurgery for Tis–T2 Glottic Cancer

JOURNAL=Frontiers in Oncology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2017.00245

DOI=10.3389/fonc.2017.00245

ISSN=2234-943X

ABSTRACT=<sec id="ST1"><title>Introduction</title><p>Transoral laser microsurgery (TLM) represents one of the most effective treatment strategies for Tis–T2 glottic squamous cell carcinomas (SCC). The prognostic influence of close/positive margins is still debated, and the role of narrow band imaging (NBI) in their intraoperative definition is still to be validated on large cohort of patients. This study analyzed the influence of margin status on recurrence-free survival (RFS) and disease-specific survival (DSS).</p></sec><sec id="ST2"><title>Methods</title><p>We retrospectively studied 507 cases of pTis–T1b (Group A) and 127 cases of pT2 (Group B) glottic SCC. We identified the following margin status: negative (<italic>n</italic> = 232), close superficial (<italic>n</italic> = 79), close deep (CD) (<italic>n</italic> = 35), positive single superficial (<italic>n</italic> = 146), positive multiple superficial (<italic>n</italic> = 94), and positive deep (<italic>n</italic> = 48) and analyzed their impact on RFS and DSS. Close margins were defined by tumor-margin distance &lt;1 mm. Pre-TLM margins were defined by white light in 323 patients, whereas NBI was employed in 311 patients.</p></sec><sec id="ST3"><title>Results</title><p>In Group A, DSS and RFS were reduced in positive multiple superficial and positive deep margins (DSS = 96.1 and 97%, both <italic>p</italic> &lt; 0.05; RFS = 72%, <italic>p</italic> &lt; 0.001 and 75.8%, <italic>p</italic> &lt; 0.01). In Group B, DSS was reduced in positive multiple superficial margins (82.4%, <italic>p</italic> &lt; 0.05). RFS was reduced in positive single superficial, positive multiple superficial, and positive deep margins (62.5, 41.2, and 53.3%, <italic>p</italic> &lt; 0.01). In the entire population, RFS was reduced in CD margins (77.1%, <italic>p</italic> &lt; 0.05). Use of NBI led to improvement in RFS and DSS.</p></sec><sec id="ST4"><title>Conclusion</title><p>The study indicates that close and positive single superficial margins do not affect DSS. By contrast, all types of margin positivity predict the occurrence of relapses, albeit with different likelihood, depending on stage/margin type. CD margins should be considered as a single risk factor. Use of NBI granted better intraoperative margins definition.</p></sec>