AUTHOR=Azria David , Brengues Muriel , Gourgou Sophie , Bourgier Celine 

TITLE=Personalizing Breast Cancer Irradiation Using Biology: From Bench to the Accelerator

JOURNAL=Frontiers in Oncology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00083

DOI=10.3389/fonc.2018.00083

ISSN=2234-943X

ABSTRACT=<p>While adjuvant treatments of early breast cancers (BCs) had significantly improved patients’ overall survival, some of them will still develop locoregional relapses and/or severe late radio-induced toxicities. Here, we propose to review how to personalize locoregional treatment by identifying patients at high and low risk of locoregional relapse, patients at risk of late radio-induced side effects. We will, therefore, discuss how to enhance BC radiosensitivity. Finally, we will address how personalized radiotherapy could be implemented in prospective clinical trials.</p>