AUTHOR=Loewendorf Andrea I. , Csete Marie , Flake Alan 

TITLE=Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)

JOURNAL=Frontiers in Pharmacology

VOLUME=5

YEAR=2015

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2014.00282

DOI=10.3389/fphar.2014.00282

ISSN=1663-9812

ABSTRACT=<p><italic>In utero</italic> hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT.</p>