AUTHOR=Morales Paula , Reggio Patricia H. , Jagerovic Nadine 

TITLE=An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

JOURNAL=Frontiers in Pharmacology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00422

DOI=10.3389/fphar.2017.00422

ISSN=1663-9812

ABSTRACT=<p>Cannabidiol (CBD) has been traditionally used in <italic>Cannabis</italic>-based preparation, however historically, it has received far less interest as a single drug than the other components of <italic>Cannabis</italic>. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging.</p>