AUTHOR=Naz Sadia , Farooq Umar , Khan Ajmal , Khan Haroon , Karim Nasiara , Sarwar Rizwana , Hussain Javid , Rauf Abdur 

TITLE=Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.

JOURNAL=Frontiers in Pharmacology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00469

DOI=10.3389/fphar.2017.00469

ISSN=1663-9812

ABSTRACT=<p>Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, <italic>Fragaria vesca</italic> var. <italic>nubicola</italic> Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (<bold>1</bold>) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (<bold>2</bold>) based on spectroscopic data through IR, UV, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds <bold>1</bold> and <bold>2</bold> were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.</p>