AUTHOR=Long Wenyong , Yi Yang , Chen Shen , Cao Qi , Zhao Wei , Liu Qing 

TITLE=Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma

JOURNAL=Frontiers in Pharmacology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00495

DOI=10.3389/fphar.2017.00495

ISSN=1663-9812

ABSTRACT=<p>Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.</p>