AUTHOR=He Yanjing , Liu Shaoyu , Zhang Zhe , Liao Chengcheng , Lin Fan , Yao Wanzhen , Chen Yahong 

TITLE=Imbalance of Endogenous Hydrogen Sulfide and Homocysteine in Chronic Obstructive Pulmonary Disease Combined with Cardiovascular Disease

JOURNAL=Frontiers in Pharmacology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00624

DOI=10.3389/fphar.2017.00624

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Considerable studies showed associations between chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD), we evaluated the role of endogenous hydrogen sulfide (H<sub>2</sub>S)/homocysteine (Hcy) in patients with COPD combined with CVD.</p><p><bold>Methods:</bold> Fifty one stable patients with COPD were enrolled (25 COPD, 26 COPD + CVD). Lung function, sputum, peripheral blood samples, serum H<sub>2</sub>S, Hcy, high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) levels were measured. Dyspnea, symptoms and quality of life were quantified by modified Medical Research Council dyspnea scale (mMRC), COPD assessment test (CAT) and St. George’s Respiratory Questionnaire (SGRQ).</p><p><bold>Results:</bold> Compared with COPD group, waist circumference and body mass index (BMI) were higher in COPD + CVD group, mMRC, CAT and activity scores were also higher, high density lipoprotein cholesterol (HDL-C) was lower, total cells, neutrophils (%) in sputum and serum hs-CRP level were higher, whereas macrophages (% ) in sputum was lower. H<sub>2</sub>S and Hcy levels from COPD + CVD group were higher than those from COPD group, but H<sub>2</sub>S/Hcy ratio was lower. With increasing COPD severity, H<sub>2</sub>S level was decreased, however, Hcy level was increased. H<sub>2</sub>S level was positively correlated with FEV<sub>1</sub>/FVC, FEV<sub>1</sub>% predicted, lymphocytes (%) and macrophages (%) in sputum, but negatively correlated with smoking pack-years and neutrophils (%) in sputum. Hcy level was positively correlated with BMI and total cells in sputum. The ratio of H<sub>2</sub>S/Hcy was also positively correlated with FEV<sub>1</sub>/FVC, but negatively correlated with total cells in sputum.</p><p><bold>Conclusion:</bold> The imbalance of H<sub>2</sub>S/Hcy may be involved in the pathogenesis of COPD combined with CVD and provide novel targets for therapy.</p>