AUTHOR=Bouatou Yassine , Stenz Ludwig , Ponte Belen , Ferrari Serge , Paoloni-Giacobino Ariane , Hadaya Karine 

TITLE=Recipient rs1045642 Polymorphism Is Associated With Office Blood Pressure at 1-Year Post Kidney Transplantation: A Single Center Pharmacogenetic Cohort Pilot Study

JOURNAL=Frontiers in Pharmacology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00184

DOI=10.3389/fphar.2018.00184

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Corticosteroids are associated with reduced bone mineral density (BMD), as well as water and salt retention, leading to hypertension. They are substrates for P-glycoprotein, a protein coded by the highly polymorphic <italic>ABCB1</italic> gene. We hypothesized that one <italic>ABCB1</italic> polymorphism, rs1045642, is associated with blood pressure and BMD parameters at 1-year post kidney transplantation (KT).</p><p><bold>Methods:</bold> Rs1045642 was genotyped using pyrosequencing in 40 KT recipients. Both dominant (CC vs. CT + TT) and codominant (CC vs. CT vs. TT) genetic models (analysis of variance from linear regressions) were adjusted for confounding variables (age, sex, type of nephropathy, glomerular filtration rate, and corticosteroid use at 1 year).</p><p><bold>Results:</bold> Rs1045642 genotypes were significantly associated with systolic (SBP) and diastolic (DBP) blood pressure 1-year post-transplantation, independent of the genetic model used (adjusted codominant model: SBP <italic>p</italic>-value = 0.015, DBP <italic>p</italic>-value = 0.038; adjusted dominant model: SBP <italic>p</italic>-value = 0.003, DBP <italic>p</italic>-value = 0.011). A non-statistically significant trend was observed for an association between rs1045642 and BMD change at 1-year post-KT.</p><p><bold>Conclusions:</bold> Rs1045642 is significantly associated with higher BP 1 year after KT. Further investigations are necessary to confirm the role of rs1045642 in corticosteroid-related adverse effects.</p>