AUTHOR=Kohr Mark , Roof Steve , Zweier Jay , Ziolo Mark T.

TITLE=Modulation of myocardial contraction by peroxynitrite

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00468

DOI=10.3389/fphys.2012.00468

ISSN=1664-042X

ABSTRACT=<p>Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca<sup>2+</sup> handling, proposed signaling pathways, and protein end-targets.</p>