AUTHOR=McCarroll Joshua A. , Naim Stephanie , Sharbeen George , Russia Nelson , Lee Julia , Kavallaris Maria , Goldstein David , Phillips Phoebe A. 

TITLE=Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

JOURNAL=Frontiers in Physiology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2014.00141

DOI=10.3389/fphys.2014.00141

ISSN=1664-042X

ABSTRACT=<p>Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.</p>