AUTHOR=de Bono Bernard , Safaei Soroush , Grenon Pierre , Nickerson David P. , Alexander Samuel , Helvensteijn Michiel , Kok Joost N. , Kokash Natallia , Wu Alan , Yu Tommy , Hunter Peter , Baldock Richard A. TITLE=The Open Physiology workflow: modeling processes over physiology circuitboards of interoperable tissue units JOURNAL=Frontiers in Physiology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00024 DOI=10.3389/fphys.2015.00024 ISSN=1664-042X ABSTRACT=

A key challenge for the physiology modeling community is to enable the searching, objective comparison and, ultimately, re-use of models and associated data that are interoperable in terms of their physiological meaning. In this work, we outline the development of a workflow to modularize the simulation of tissue-level processes in physiology. In particular, we show how, via this approach, we can systematically extract, parcellate and annotate tissue histology data to represent component units of tissue function. These functional units are semantically interoperable, in terms of their physiological meaning. In particular, they are interoperable with respect to [i] each other and with respect to [ii] a circuitboard representation of long-range advective routes of fluid flow over which to model long-range molecular exchange between these units. We exemplify this approach through the combination of models for physiology-based pharmacokinetics and pharmacodynamics to quantitatively depict biological mechanisms across multiple scales. Links to the data, models and software components that constitute this workflow are found at http://open-physiology.org/.