AUTHOR=Kamber Maria , Papalazarou Vasileios , Rouni Georgia , Papageorgopoulou Evagelia , Papalois Apostolos , Kostourou Vassiliki TITLE=Angiotensin II inhibitor facilitates epidermal wound regeneration in diabetic mice JOURNAL=Frontiers in Physiology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00170 DOI=10.3389/fphys.2015.00170 ISSN=1664-042X ABSTRACT=

Tissue regeneration and wound healing are severely impaired in diabetes and are associated with poor circulation and dysfunctional blood vessels. Angiotensin II inhibitors are anti-hypertensive drugs used in clinical practice to regulate blood pressure and could affect tissue remodeling. We hypothesize that blocking angiotensin II, using Losartan, could facilitate tissue regeneration in diabetic mice. To this end, we established an experimental model of wound healing in streptozotocin-induced diabetic mice. Our data demonstrated that Losartan accelerates wound repair and normalizes wound stromal responses, having a beneficial role in wounds of diabetic individuals. Our findings highlight a potential therapeutic use of Losartan in improving wound repair in diabetic conditions.