AUTHOR=Li Yan-yan , Zhou Yan-hong , Gong Ge , Geng Hong-yu , Yang Xin-xing 

TITLE=TGF-β1 Gene -509C/T Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis Involving 11,701 Subjects

JOURNAL=Frontiers in Physiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2017.00108

DOI=10.3389/fphys.2017.00108

ISSN=1664-042X

ABSTRACT=<p><bold>Background:</bold> The <italic>transforming growth factor-β1 (TGF-β1)</italic> gene -509C/T polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. However, the individual studies results are still inconsistent.</p><p><bold>Objective and methods:</bold> To investigate the relationship between <italic>TGF-β1</italic> gene -509C/T polymorphism and CAD, a meta-analysis involving 11,701 participants from 8 individual studies was conducted. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals were evaluated by using random or fixed effect models.</p><p><bold>Results:</bold> A significant association between <italic>TGF-β1</italic> gene -509C/T polymorphism and CAD was detected in the total population under allelic (OR: 1.130, 95% CI: 1.060–1.200, <italic>P</italic> = 0.0001), recessive (OR: 1.390, 95% CI: 1.100–1.750, <italic>P</italic> = 0.006), dominant (OR: 0.857, 95% CI: 0.785–0.935, <italic>P</italic> = 2.507 × 10<sup>−4</sup>), homozygous (OR: 1.258, 95% CI: 1.098–1.442, <italic>P</italic> = 0.001), heterozygous (OR: 1.147, 95% CI: 1.046–1.257, <italic>P</italic> = 0.003), and additive genetic models (OR: 1.131, 95% CI: 1.063–1.204, <italic>P</italic> = 5.442 × 10<sup>−5</sup>). In the subgroup analysis, there was a significant association between them in Chinese population under all of the genetic models (<italic>P</italic> &lt; 0.05), except under the heterozygous genetic model (<italic>P</italic> &gt; 0.05). In the Caucasian subgroup, a significant association between them was also detected under all of the genetic models (<italic>P</italic> &lt; 0.05), except under the recessive genetic model (<italic>P</italic> &gt; 0.05).</p><p><bold>Conclusions:</bold><italic>TGF-β1</italic> gene -509C/T polymorphism was significantly associated with increased CAD risk. The people with T allele of <italic>TGF-β1</italic> gene -509C/T polymorphism might be predisposed to CAD.</p>