AUTHOR=Meng Lai-Sheng , Li Ying-Qiu , Liu Meng-Qian , Jiang Ji-Hong 

TITLE=The Arabidopsis ANGUSTIFOLIA3-YODA Gene Cascade Induces Anthocyanin Accumulation by Regulating Sucrose Levels

JOURNAL=Frontiers in Plant Science

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2016.01728

DOI=10.3389/fpls.2016.01728

ISSN=1664-462X

ABSTRACT=<p>Anthocyanin accumulation specifically depends on sucrose (Suc) signaling/levels. However, the gene cascades specifically involved in the Suc signaling/level-mediated anthocyanin biosynthetic pathway are still unknown. <italic>Arabidopsis ANGUSTIFOLIA3</italic> (<italic>AN3</italic>), a transcription coactivator, is involved in the regulation of leaf shape and drought tolerance. Recently, an <italic>AN3-CONSTITUTIVE PHOTOMORPHOGENIC 1</italic> gene cascade has been reported to regulate the light signaling-mediated anthocyanin accumulation. Target gene analysis indicates that <italic>AN3</italic> is associated with the <italic>YODA</italic> (<italic>YDA</italic>) promoter, a mitogen-activated protein kinase kinase kinase, <italic>in vivo</italic> for inducing anthocyanin accumulation. Indeed, loss-of-function mutants of <italic>YDA</italic> showed significantly increased anthocyanin accumulation. <italic>YDA</italic> mutation can also suppress the decrease in <italic>an3-4</italic> anthocyanin accumulation. Further analysis indicates that the mutations of <italic>AN3</italic> and <italic>YDA</italic> disrupt the normal Suc levels because of the changes of invertase activity in mutants of <italic>an3</italic> or <italic>yda</italic>, which in turn induces the alterations of anthocyanin accumulation in mutants of <italic>an3</italic> or <italic>yda</italic> via unknown regulatory mechanisms.</p>