AUTHOR=Rubino Tiziana , Parolaro Daniela 

TITLE=Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence

JOURNAL=Frontiers in Psychiatry

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2015.00056

DOI=10.3389/fpsyt.2015.00056

ISSN=1664-0640

ABSTRACT=<p>The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the different possible underlying mechanisms, the consistent dimorphism in the endocannabinoid system and delta9-tetrahydrocannabinol metabolism may play a part. All the collected data point to the need of including females in basic research as well as of analyzing results for sex differences in epidemiological studies.</p>