AUTHOR=Myneni Ajay A. , Chang Shen-Chih , Niu Rungui , Liu Li , Zhao Baoxing , Shi Jianping , Han Xiaoyou , Li Jiawei , Su Jia , Yu Shunzhang , Zhang Zuo-Feng , Mu Lina 

TITLE=Ataxia Telangiectasia-Mutated (ATM)Polymorphisms and Risk of Lung Cancer in a Chinese Population

JOURNAL=Frontiers in Public Health

VOLUME=5

YEAR=2017

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2017.00102

DOI=10.3389/fpubh.2017.00102

ISSN=2296-2565

ABSTRACT=<sec id="ST1"><title>Background</title><p>The ataxia telangiectasia-mutated (<italic>ATM</italic>) gene has a key role in DNA repair including activation and stabilization of <italic>p53</italic>, which implicates the importance of <italic>ATM</italic> polymorphisms in the development of cancer. This study aims to investigate the association of two <italic>ATM</italic> single-nucleotide polymorphisms (SNPs) with lung cancer, as well as their potential interaction with <italic>p53</italic> gene and other known risk factors of lung cancer.</p></sec><sec id="ST2"><title>Methods</title><p>A population-based case–control study was conducted in Taiyuan city, China with 399 cases and 466 controls matched on the distribution of age and sex of cases. The two <italic>ATM</italic> gene SNPs, <italic>ATM</italic>rs227060 and <italic>ATM</italic>rs228589 as well as <italic>p53</italic> gene SNP, <italic>p53</italic>rs1042522 were genotyped using Sequenom platform. Unconditional logistic regression models were used to estimate crude and adjusted odds ratios (aOR) and 95% confidence intervals (CIs). Adjusted models controlled for age, sex, and smoking status.</p></sec><sec id="ST3"><title>Results</title><p>The study showed that TT genotype of <italic>ATM</italic>rs227060 (aOR = 1.58, 95% CI: 1.06–2.35) and AA genotype of <italic>ATM</italic>rs228589 were significantly associated with lung cancer (aOR = 1.50, 95% CI: 1.08–2.08) in a recessive model. Additionally, carrying variant genotypes of <italic>ATM</italic>rs227060 (TT), <italic>ATM</italic>rs228589 (AA), and <italic>p53</italic>rs1042522 (CC) concomitantly was associated with much higher risk (aOR = 3.68, 95% CI: 1.43–9.45) of lung cancer than carrying variant genotypes of any one of the above three SNPs. We also found multiplicative and additive interaction between tea drinking and <italic>ATM</italic>rs227060 in association with lung cancer.</p></sec><sec id="ST4"><title>Conclusion</title><p>This study indicates that <italic>ATM</italic> gene variants might be associated with development of lung cancer in Chinese population. These results need to be validated in larger and different population samples.</p></sec>