Research Topic

Structure-based drug design for diagnosis and treatment of neurological diseases

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Monoamine neurotransmitters such as dopamine, noradrenaline, histamine and serotonin play a central role in the pathophysiology of major neuropsychiatric illnesses, such as anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementias. The aim of this ...

Monoamine neurotransmitters such as dopamine, noradrenaline, histamine and serotonin play a central role in the pathophysiology of major neuropsychiatric illnesses, such as anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementias. The aim of this Research Topic is to highlight interdisciplinary research using drug design, data-mining, structure-based drug design, medicinal chemistry and biological investigation in vitro and in vivo disease models, with input from behavioral and genetic studies. In this issue we encourage submissions of basic and/or clinical studies and review papers that summarize current knowledge and point out important deficiencies in our current understanding of the important monoamines systems.


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