Research Topic

Drug Repurposing

  • Submission closed.

About this Research Topic

Drug repurposing, also known as drug repositioning, is a strategy that seeks to reuse existing, licensed medications for new medical indications, often in diseases with very different profiles to that for which the drug was originally developed. Repurposing offers a number of significant advantages in comparison with de novo drug development. These include the availability of extensive pharmacokinetic, pharmacodynamic and safety data, (with data on both common and rare adverse events) and an understanding of relevant molecular targets and mechanisms of action.

Additionally the repurposing of generic medications is appealing at a time when economic pressures are negatively impacting health systems globally. The potential for cheap generic medications to tackle cancer and other serious medical conditions in low and middle income countries is particularly appealing. The combination of drug repurposing and metronomic chemotherapy, often termed metronomics, is particularly appealing in this respect. However, more widespread adoption of the repurposing strategy is often hampered by a lack industry engagement and poor financial incentives. Therefore, while the advantages are clear, there are many challenges to overcome in order to show clinical efficacy, which is the most important criterion by which repurposing should be judged.

This Research Topic provides a focus on drug repurposing, particularly in a clinical context. Potential articles will focus on translational and clinical studies, case reports, trial rationales and so on. An additional focus will be on regulatory and institutional issues related to repurposing, including drug licensing, financial disincentives and other factors associated with translating trial results to clinical practice.


Important Note: All contributions to this Research Topic must be in line with the scope of the specialty and field to which they are submitted, as defined in their mission statements. Manuscripts discovered during any stage of peer review to be outside of the scope may be transferred to a suitable section or field, or withdrawn from review.

Drug repurposing, also known as drug repositioning, is a strategy that seeks to reuse existing, licensed medications for new medical indications, often in diseases with very different profiles to that for which the drug was originally developed. Repurposing offers a number of significant advantages in comparison with de novo drug development. These include the availability of extensive pharmacokinetic, pharmacodynamic and safety data, (with data on both common and rare adverse events) and an understanding of relevant molecular targets and mechanisms of action.

Additionally the repurposing of generic medications is appealing at a time when economic pressures are negatively impacting health systems globally. The potential for cheap generic medications to tackle cancer and other serious medical conditions in low and middle income countries is particularly appealing. The combination of drug repurposing and metronomic chemotherapy, often termed metronomics, is particularly appealing in this respect. However, more widespread adoption of the repurposing strategy is often hampered by a lack industry engagement and poor financial incentives. Therefore, while the advantages are clear, there are many challenges to overcome in order to show clinical efficacy, which is the most important criterion by which repurposing should be judged.

This Research Topic provides a focus on drug repurposing, particularly in a clinical context. Potential articles will focus on translational and clinical studies, case reports, trial rationales and so on. An additional focus will be on regulatory and institutional issues related to repurposing, including drug licensing, financial disincentives and other factors associated with translating trial results to clinical practice.


Important Note: All contributions to this Research Topic must be in line with the scope of the specialty and field to which they are submitted, as defined in their mission statements. Manuscripts discovered during any stage of peer review to be outside of the scope may be transferred to a suitable section or field, or withdrawn from review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..
Yearly

total views article views article downloads topic views

 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top